6-甲基-2-(苯乙炔基)吡啶盐酸盐

中文名	MPEP HYDROCHLORIDE
英文名	MPEP HYDROCHLORIDE
别名	MPEP盐酸盐 2-甲基-6-(苯基炔基)吡啶盐酸盐 2-甲基-6-(苯基乙炔基)吡啶盐酸盐 6-甲基-2-(苯乙炔基)吡啶盐酸盐
英文别名	MPEP HYDROCHLORIDE 6-methyl-2-(phenylethynyl)pyridine Pyridine, 6-methyl-2-(phenylethynyl)- 2-methyl-6-(phenylethynyl)pyridine(MPEP) MPVP replace pvp,White Crystal, New Stock! 6-Methyl-2-(phenylethynyl)pyridine hydrochloride
CAS	219911-35-0
化学式	C14H11N.ClH
分子量	229.709
InChIKey	PKDHDJBNEKXCBI-UHFFFAOYSA-N
熔点	145-146℃
溶解度	DMSO: 10 mg/mL
存储条件	room temp
稳定性	从提供的购买之日起稳定1年。DMSO或乙醇中的溶液可以在-20 °C下储存长达1个月。
外观	固体
颜色	off-white
体外研究	MPEP does not show agonist or antagonist activity at 100 mM on human mGlu2, -3, -4a, -7b, and -8a receptors nor at 10 μM on the human mGlu6 receptor.
体内研究	MPEP (1-30 mg/kg) induces anxiolytic-like effects in the conflict drinking test and the elevated plus-maze test in rats as well as in the four-plate test in mice. MPEP (1-20 mg/kg) does shorten the immobility time in a tail suspension test in mice, however it is inactive in the behavioural despair test in rats. MPEP (30 mg/kg i.p.) slightly but significantly increases (by 39%) the number of punished crossings in the four-plate test, lower doses of the compound (3 and 10 mg/kg) does not affect the number of punished crossings in that test (F (3,36)=3.240, P<0.05). MPEP (1, 10 and 20 mg/kg) significantly (by 55% after the highest dose), (F(3,28)=15.47, P<0.001) decreases the immobility time of mice in the tail suspension test. Its efficacy is similar to that of imipramine (20 mg/kg), used as the positive standard. Animal Model: Male Wistar rats (200 ± 250 g). Dosage: IP or PO. Administration: 0.3, 1 and 10 mg/kg, i.p. (Conflict drinking test). Result: At a dose of 0.3 mg/kg was not ffective, at doses of 1 and 10 mg/kg i.p. significantly (F (3,30)=11.193, P<0.001), increased the number of shocks (by 330 and 507%, respectively) accepted during the experimental session in the Vogel test. Animal Model: Male Wistar rats (200 ± 250 g). Dosage: IP or PO. Administration: 1, 3 and 10 mg/kg, i.p. or 10 and 30 mg/kg, p.o.(Elevated plus-maze test). Result: Administered at a dose of 1 mg kg71 i.p. did not change the entries into and time spent in the open arms. At doses of 3 and 10 mg/kg i.p. significantly (F (3,24)=22.978, P<0.001) dose-dependently increased the time spent in the open arms (up to 45 and 74%, respectively), and the percentage of entries into the open arms (up to 48 and 68%, respectively, F(3,24)=5.678, P<.01 at doses of and mg i.p. significantly increased the total number entries reduced about time spent not shown in arms type> At the dose of 30 mg/kg (po, but not 10 mg/kg) significantly (up to 64%, F (2,16)=14.249, P<0.001) increased the percentage of the time spent in the open arms and the percentage of entries into the open arms (up to 63%, F (2,16)=7.295, P<0.01). MPEP given p.o. in both doses used did not change the total number of entries nor the total time spent in the arms (either type).
WGK Germany	3

6-甲基-2-(苯乙炔基)吡啶盐酸盐 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	4.353 ml	21.767 ml	43.533 ml
5 mM	0.871 ml	4.353 ml	8.707 ml
10 mM	0.435 ml	2.177 ml	4.353 ml
5 mM	0.087 ml	0.435 ml	0.871 ml

最后更新：2024-01-02 23:10:35

6-甲基-2-(苯乙炔基)吡啶盐酸盐 - 简介

MPEP HYDROCHLORIDE（也称为2-Methyl-6-(phenylethynyl)pyridine hydrochloride）是一种化合物。它是一种白色至淡黄色粉末，可溶于水和有机溶剂。

MPEP HYDROCHLORIDE主要用于研究和实验室应用。它是一种非竞争性、选择性的mGluR5（谷氨酸代谢型谷氨酸受体5）拮抗剂，具有抑制突触可塑性、记忆和认知功能的作用。其特殊的药理特性，MPEP HYDROCHLORIDE被广泛应用于神经科学的研究中，特别是研究与神经退行性疾病和精神障碍相关的机制。

MPEP HYDROCHLORIDE的制备方法一般采用合成化学方法。常用的合成路线是通过苯基乙炔基二乙胺和乙酸酐的反应合成。

安全信息：在处理或使用MPEP HYDROCHLORIDE时，应遵循一般化学品安全操作规范。避免接触皮肤、眼睛或呼吸道，佩戴适当的个人防护装备如实验手套、护目镜和防护口罩。在储存和处置过程中应当注意避免火源和湿气。如不慎吸入或接触，应立即清洗受到影响的部位，并及时就医。使用前，应详细阅读产品安全说明书和化学品相关文献，以确保安全操作。

最后更新：2024-04-10 22:29:15

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产品名: MPEP盐酸盐去供应商网站查看询盘
CAS: 219911-35-0
产地: 上海
规格: M860991
价格: 10mg-108,100mg-549,250mg-927
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产品名: 2-甲基-6-(苯基乙炔基)吡啶盐酸盐去供应商网站查看询盘
CAS: 219911-35-0
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包装: 5mg /瓶
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产品名: MPEP HYDROCHLORIDE 去供应商网站查看询盘
CAS: 219911-35-0
产地: 上海
规格: 98%
价格: 5mg 216,10mg 312,25mg 640,50mg 1240,100mg 2160,200mg 3920
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